• Journal of virology · Aug 2008

    A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters.

    • Elaine W Lamirande, Marta L DeDiego, Anjeanette Roberts, Jadon P Jackson, Enrique Alvarez, Tim Sheahan, Wun-Ju Shieh, Sherif R Zaki, Ralph Baric, Luis Enjuanes, and Kanta Subbarao.
    • Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA.
    • J. Virol. 2008 Aug 1; 82 (15): 7721-4.

    AbstractThe immunogenicity and protective efficacy of a live attenuated vaccine consisting of a recombinant severe acute respiratory syndrome (SARS) coronavirus lacking the E gene (rSARS-CoV-DeltaE) were studied using hamsters. Hamsters immunized with rSARS-CoV-DeltaE developed high serum-neutralizing antibody titers and were protected from replication of homologous (SARS-CoV Urbani) and heterologous (GD03) SARS-CoV in the upper and lower respiratory tract. rSARS-CoV-DeltaE-immunized hamsters remained active following wild-type virus challenge, while mock-immunized hamsters displayed decreased activity. Despite being attenuated in replication in the respiratory tract, rSARS-CoV-DeltaE is an immunogenic and efficacious vaccine in hamsters.

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