• The lancet oncology · Mar 2021

    Review

    The role of radiotherapy in patients with solid tumours after solid organ transplantation: a systematic review.

    • Rosario Mazzola, Francesco Cuccia, Alessandro Bertani, Slavisa Tubin, Pier Giulio Conaldi, Stefanie Corradini, Maria Tolia, Markus Guba, and Filippo Alongi.
    • Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy. Electronic address: rosario.mazzola@sacrocuore.it.
    • Lancet Oncol. 2021 Mar 1; 22 (3): e93-e104.

    AbstractFor patients diagnosed with cancer who have previously received an organ transplant, radiotherapy represents a challenging clinical scenario without well established care algorithms. Immunosuppressive therapy can be a cause for concern among clinicians treating this category of patients. Potential immune modulation following irradiation could affect recipient organ tolerance and the outcomes of the transplantation itself. The main aim of this systematic review was to define the safety and effectiveness of radiotherapy in patients diagnosed with cancer who have previously received an organ transplant. We searched PubMed and Embase for articles published between Jan 1, 1995, and April 30, 2020 for studies in patients who had undergone radiotherapy for post-transplantation malignancies. The Review is framed by the PICO (population, intervention, control, and outcomes) criteria, and primarily focuses on modern treatment techniques.Copyright © 2021 Elsevier Ltd. All rights reserved.

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