• Aust Prescr · Feb 2021

    Review

    Is it time to stop using statistical significance?

    • Oliver Frank, Cw Michael Tam, and Joel Rhee.
    • Oakden Medical Centre, Hillcrest, South Australia.
    • Aust Prescr. 2021 Feb 1; 44 (1): 16-18.

    AbstractThe important first step in the critical appraisal of a randomised trial is not an evaluation of the statistical analyses. The most important aspect to consider when reviewing a study of a new drug is the appropriateness and quality of the trial design and methods The next most important aspect is the effect size of different treatments and its clinical significance. Rather than reporting statistical significance, studies should report the difference between treatments and its precision Over-reliance on statistical significance and p values may lead to incorrect conclusions. Trial reports about drugs should therefore avoid the term statistical significance and quote p values with caution.(c) NPS MedicineWise.

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