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Leukemia & lymphoma · Aug 2005
Case ReportsCongenital MLL-positive B-cell acute lymphoblastic leukemia (B-ALL) switched lineage at relapse to acute myelocytic leukemia (AML) with persistent t(4;11) and t(1;6) translocations and JH gene rearrangement.
- Jie-Gen Jiang, Elizabeth Roman, Subhadra V Nandula, Vundavalli V S Murty, Govind Bhagat, and Bachir Alobeid.
- Department of Pathology, Columbia University, New York, NY 10032, USA.
- Leuk. Lymphoma. 2005 Aug 1; 46 (8): 1223-7.
AbstractCongenital acute leukemia is a rare form of childhood leukemia, in which lineage conversion at relapse is very rarely reported. Here we describe a case of congenital B-cell acute lymphoblastic leukemia (B-ALL) with t(4;11) and t(1;6) translocations, which at relapse underwent a switch to monocytic lineage with persistence of the original cytogenetic translocations and clonal rearrangement of the JH gene. Similar to the other described cases of congenital acute leukemia with lineage conversion, our case had a MLL gene rearrangement and followed an aggressive clinical course.
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