• Michelangelo Bartolo, Stefano Bargellesi, Carlo Alberto Castioni, Domenico Intiso, Andrea Fontana, Massimiliano Copetti, Federico Scarponi, Donatella Bonaiuti, and Intensive Care and Neurorehabilitation Italian Study Group.
• Neurorehabilitation, HABILITA Care and Research Rehabilitation Hospitals, 24044 Bergamo, Italy. michelangelobartolo@habilita.it.
• J Rehabil Med. 2017 Nov 21; 49 (9): 715-722.

ObjectiveTo determine whether early mobilization of patients with severe acquired brain injury, performed in the intensive/neurointensive care unit, influences functional outcome.DesignProspective observational study.SettingFourteen centres in Italy.SubjectsA total of 103 consecutive patients with acquired brain injury.MethodsClinical, neurological and functional data, including the Glasgow Coma Scale (GCS), Disability Rating Scale (DRS), the Rancho Los Amigos Levels of Cognitive Functioning (LCF), Early Rehabilitation Barthel Index (ERBI), Glasgow Outcome Scale (GOS), and Functional Independence Measure (FIM) were collected at admission and every 3?5 days until discharge from the intensive/neurointensive care unit. Patients were divided into mobilization and no mobilization groups, depending on whether they received mobilization. Data were analysed by intragroup and intergroup analysis using a multilevel regression model.ResultsSixty-eight patients were included in the mobilization group. At discharge, both groups showed significant improvements in GCS, DRS, LCF and ERBI scores. The mobilization group showed significantly better improvements in FIM cognitive, GOS and ERBI. The patients in the mobilization group stayed longer in the intensive care unit (p=0.01) and were more likely to be discharged to intensive rehabilitation at a significantly higher rate (p=0.002) than patients in the no mobilization group. No adverse events were reported in either group.ConclusionEarly mobilization appears to favour the clinical and functional recovery of patients with severe acquired brain injury in the intensive care unit.

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