• Moon Joo Cheong, Sungchul Kim, Jee Su Kim, Hyeryun Lee, Yeoung-Su Lyu, Yu Ra Lee, Byeonghyeon Jeon, and Hyung Won Kang.
• Rare Diseases Integrative Treatment Research Institute, Wonkwang University, Jangheung Integrative Medical Hospital, Anyang-myeon, Jangheung-gun, Jeollanam-do.
• Medicine (Baltimore). 2021 Mar 5; 100 (9): e24652e24652.

BackgroundThis systematic review investigated the clinical effects of inhalation aromatherapy for the treatment of sleep problems such as insomnia.MethodsStudies on sleep problems and inhalation aromatherapy, published in Korean and international journals, were included in the meta-analysis. Five domestic and international databases, respectively each, were used for the literature search. Keywords included sleep disorder, sleep problems, insomnia, and aroma inhalation, and the related literature was further searched. After the screening, selected articles were assessed for their quality and conducted the risk of bias using RevMan 5.0, a systematic literature review was then conducted. A meta-analysis comparing the averages was conducted on studies that reported numerical values. Additionally, meta-analysis of variance and meta-regression analyses were performed.ResultsMeta-analysis of the 34 studies using the random-effects model revealed that the use of aromatherapy was highly effective in improving sleep problems such as insomnia, including quantitative and qualitative sleep effects (95% confidence interval [CI], effect sizes = 0.6491). Subgroup analysis revealed that the secondary outcomes including stress, depression, anxiety, and fatigue were significantly effective. The single aroma inhalation method was more effective than the mixed aroma inhalation method. Among the single inhalation methods, the lavender inhalation effect was the greatest.ConclusionInhalation aromatherapy is effective in improving sleep problems such as insomnia. Therefore, it is essential to develop specific guidelines for the efficient inhalation of aromatherapy.Ethics And DisseminationEthical approval is not required because individual patient data are not included. The findings of this systematic review were disseminated through peer-reviewed publications or conference presentations.Prospero Registration NumberCRD42020142120.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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