• Medicine · Mar 2021

    Association of chronic rhinosinusitis with bronchial asthma and its severity: A protocol for systematic review and meta-analysis.

    • Yangwang Pan and Hongrui Zang.
    • Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education of China, Beijing, PR China.
    • Medicine (Baltimore). 2021 Mar 5; 100 (9): e24772e24772.

    BackgroundTo explore the association of chronic rhinosinusitis (CRS) with bronchial asthma (BA) as well as its severity.MethodsA comprehensive database search will be performed from PubMed, Embase, Cochrane Library, and Web of science for related literatures. Heterogeneity test will be used to assess each outcome indicator. If heterogeneity statistics I2 ≥ 50%, the random effects model will be applied; if I2 < 50%, the fixed effects model will be performed. Sensitivity analysis will be performed in all models. STATA 15.0 software (Stata Corporation, College Station, TX) will be used for statistical analysis. Risk ratio (RR) will be used as the effect size for enumeration data. P < .05 is considered statistically significant.ConclusionThis study will evaluate the association of CRS with the prevalence of BA as well as its severity.Osf Registration Number10.17605/OSF.IO/GCTM9.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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