• Jia-Ming Chen, Ping-Fang Chiu, Feng-Mei Wu, Po-Chi Hsu, Li-Jyun Deng, Chia-Chu Chang, John Y Chiang, and Lun-Chien Lo.
• Graduate Institute of Chinese Medicine, China Medical University, Taichung.
• Medicine (Baltimore). 2021 Mar 5; 100 (9): e25037e25037.

BackgroundTraditional Chinese medicine (TCM) tongue diagnosis plays an important role in differentiation of symptoms because the tongue reflects the physiological and pathological condition of the body. The automatic tongue diagnosis system (ATDS), which noninvasively captures tongue images, can provide objective and reliable diagnostic information. Chronic kidney disease (CKD) currently is an important global public health problem and contributor to morbidity and mortality from non-communicable diseases. Thus, it is interesting to analyze and probe the relationship between tongue examination and CKD.MethodsThis protocol is a cross-sectional, case-controlled observational study investigating the usefulness of the ATDS in clinical practice by examining its efficacy as a diagnostic tool for CKD. Volunteers over 20 years old with and without CKD will be enrolled. Tongue images will be captured and the patients divided into 2 groups: CKD group and healthy group. Nine primary tongue features will be extracted and analyzed, including tongue shape, tongue color, tooth mark, tongue fissure, fur color, fur thickness, saliva, ecchymosis, and red dots.ResultThe results of this study will systematically evaluate tongue manifestations of patients and examine its efficacy as an early detection and diagnosis of CKD.DiscussionThe aim of this protocol is to investigate discriminating tongue features to distinguish between CKD and normal people, and establish differentiating index to facilitate the noninvasive detection of CKD.Trial RegistriesClinicalTrials.gov; Identifier: NCT04708743.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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