• Croatian medical journal · Feb 2021

    Review

    Non-alcoholic fatty liver disease - a procoagulant condition?

    • Lucija Virović-Jukić, Sanja Stojsavljević-Shapeski, Jelena Forgač, Michal Kukla, and Ivana Mikolašević.
    • Lucija Virović-Jukić, Department of Gastroenterology and Hepatology, Sestre Milosrdnice University Hospital Center, Vinogradska cesta 29, 10000 Zagreb, Croatia, lucija.jukic@gmail.com.
    • Croat. Med. J. 2021 Feb 28; 62 (1): 25-33.

    AbstractNon-alcoholic fatty liver disease (NAFLD) is associated with a number of extrahepatic comorbidities and considerable cardiovascular morbidity and mortality, which is possibly related to coagulation changes associated with metabolic syndrome. Coagulation disorders are common in patients with liver disease of any etiology, and here we review possible alterations in coagulation cascade specific to NAFLD. We discuss derangements in the coagulation cascade and fibrinolysis, endothelial dysfunction, and platelet abnormalities as possible culprits for altered coagulation and explore the significance of these changes for potential treatment targets.

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