• Linda Rossini Gajšak, Željka Vogrinc, Mirela Čelić Ružić, Dina Bošnjak Kuharić, Marija Bošković, Ana Koričančić Makar, Porin Makarić, Vesna Ermakora, Ivana Kekin, Žarko Bajić, and Martina Rojnić Kuzman.
• Martina Rojnić Kuzman, Department of Psychiatry, University Hospital Center Zagreb, Kišpatićeva 12, HR-10000 Zagreb, Croatia, mrojnic@gmail.com.
• Croat. Med. J. 2021 Feb 28; 62 (1): 80-89.

AimTo analyze the difference in the salivary cortisol response to psychosocial stress between the patients with the first episode of psychosis (FEP) and the control group.MethodsWe performed a cross-sectional analysis of the baseline measurements of a prospective cohort study conducted from 2015 to 2018 at two Croatian psychiatric hospitals. The study consecutively enrolled 53 patients diagnosed with FEP and 63 healthy controls. The primary outcome was the difference in the changes of salivary cortisol concentration during the stress test. The secondary outcome was the difference in the baseline levels of salivary cortisol between patients with FEP and controls. The tertiary outcome were the correlations of salivary cortisol levels with the results of the Positive and Negative Syndrome Scale for Schizophrenia, Rosenberg Self-Esteem Scale, and the International Personality Item Pool.ResultsPatients with FEP had significantly higher baseline salivary cortisol than controls, but their salivary cortisol increased significantly less during the stress test.ConclusionPatients with FEP respond differently to stressful stimuli than controls, as shown by the increased baseline salivary cortisol and blunted cortisol response, possibly indicating a greater vulnerability to psychosocial stress.

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