• Nasim Maleki, Alan Finkel, Guoshuai Cai, Alexandra Ross, R Davis Moore, Xuesheng Feng, and X Michelle Androulakis.
• Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA.
• Curr Pain Headache Rep. 2021 Mar 5; 25 (3): 20.

Purpose Of ReviewPost-traumatic headache (PTH) consequent to mild traumatic brain injury (mTBI) is a complex, multidimensional, chronic neurological disorder. The purpose of this review is to evaluate the current neuroimaging studies on mTBI and PTH with a specific focus on brain networks and connectivity patterns.Recent FindingsWe present findings on PTH incidence and prevalence, as well as the latest neuroimaging research findings on mTBI and PTH. Additionally, we propose a new strategy in studying PTH following mTBI. The diversity and heterogeneity of pathophysiological mechanisms underlying mild traumatic brain injury pose unique challenges on how we interpret neuroimaging findings in PTH. Evaluating alterations in the intrinsic brain network connectivity patterns using novel imaging and analytical techniques may provide additional insights into PTH disease state and therefore inform effective treatment strategies.

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