• Ana R Soares de Oliveira, Jayanne Clímaco CruzKyriaKhttps://orcid.org/0000-0002-4489-702XPostgraduate Program in Food and Nutrition, Federal University of Piaui, Teresina, Brazil., Beatriz Silva MoraisJenniferJhttps://orcid.org/0000-0002-1031-7461Postgraduate Program in Food and Nutrition, Federal University of Piaui, Teresina, Brazil., Rocha Dos SantosLoanneLhttps://orcid.org/0000-0002-5418-6715Postgraduate Program in Food and Nutrition, Federal University of Piaui, Teresina, Brazil., Rodrigues de Sousa MeloStéfanyShttps://orcid.org/0000-0001-5308-3522Postgraduate Program in Food and Nutrition, Federal University of Piaui, Teresina, Brazil., Larissa C Fontenelle, Santos de SousaGustavoGhttps://orcid.org/0000-0003-0376-0585Faculty of Medical Sciences, State University of Piauí, Teresina, Brazil., Costa MaiaCarla SorayaCShttps://orcid.org/0000-0003-1535-6686State University of Ceará, Fortaleza, Brazil., Oliveira Duarte de AraújoCamillaChttps://orcid.org/0000-0002-4782-255XState University of Ceará, Fortaleza, Brazil., Leal MendesIslanneIhttps://orcid.org/0000-0003-1864-398XPostgraduate Program in Food and Nutrition, Federal University of Piaui, Teresina, Brazil., Simeone HenriquesGilbertoGhttps://orcid.org/0000-0002-9110-5427School of Nursing, Federal University of Minas Gerais, Belo Horizonte, Brazil., Costa SilvaVladimirVhttps://orcid.org/0000-0003-3109-7899Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui, Teresina, Brazil., and do Nascimento MarreiroDilinaDhttps://orcid.org/0000-0002-7550-1403Postgraduate Program in Food and Nutrition, Federal University of Piaui, Teresina, Brazil..
• Postgraduate Program in Food and Nutrition, Federal University of Piaui, Teresina, Brazil.
• Eur. J. Clin. Invest. 2021 Sep 1; 51 (9): e13538.

BackgroundSelenium deficiency appears to limit antioxidant defense in obese individuals. This study evaluated the association between adiposity indices, selenium status, and oxidative stress in obese women.MethodsThis was a cross-sectional study involving 139 women who were divided into the following two groups: the case group (obese women, n = 63) and the control group (normal-weight women, n = 76). Plasma, erythrocyte, and urinary selenium levels were determined using inductively coupled plasma optical emission spectrometry. Body weight, height, waist circumference, hip circumference and neck circumference were measured. Body mass index, waist/height ratio, conicity index, body fat index, body adiposity index, body circularity index, and visceral adiposity index were calculated. Plasma levels of thiobarbituric acid reactive substances were determined. The erythrocyte glutathione peroxidase activity was determined using an automatic biochemical analyzer and Ransel kit.ResultsObese women had selenium deficiency characterized by reduction in plasma and erythrocyte concentrations (P < .001). The urinary selenium excretion was higher in the case group compared to the control group (P < .001). Adiposity indices values and plasma concentrations of thiobarbituric acid reactive substances were significantly elevated in obese women (P < .001). There was a significant association between adiposity indices and selenium status (P < .001), and between erythrocyte selenium and erythrocyte glutathione peroxidase activity (P < .001).ConclusionObese women evaluated in the study have reduced plasma and erythrocyte concentrations of selenium and an increased urinary excretion of selenium. The correlation analysis reveals an association between intra-abdominal fat accumulation and selenium metabolism and oxidative stress.© 2021 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.

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