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Diabetes Obes Metab · Oct 2020
Meta AnalysisPrevalence of co-morbidities and their association with mortality in patients with COVID-19: A systematic review and meta-analysis.
- Awadhesh K Singh, Clare L Gillies, Ritu Singh, Akriti Singh, Yogini Chudasama, Briana Coles, Sam Seidu, Francesco Zaccardi, Melanie J Davies, and Kamlesh Khunti.
- GD Hospital & Diabetes Institute, Kolkata, India.
- Diabetes Obes Metab. 2020 Oct 1; 22 (10): 1915-1924.
AimTo estimate the prevalence of both cardiometabolic and other co-morbidities in patients with COVID-19, and to estimate the increased risk of severity of disease and mortality in people with co-morbidities.Materials And MethodsMedline, Scopus and the World Health Organization website were searched for global research on COVID-19 conducted from January 2019 up to 23 April 2020. Study inclusion was restricted to English language publications, original articles that reported the prevalence of co-morbidities in individuals with COVID-19, and case series including more than 10 patients. Eighteen studies were selected for inclusion. Data were analysed using random effects meta-analysis models.ResultsEighteen studies with a total of 14 558 individuals were identified. The pooled prevalence for co-morbidities in patients with COVID-19 disease was 22.9% (95% CI: 15.8 to 29.9) for hypertension, 11.5% (9.7 to 13.4) for diabetes, and 9.7% (6.8 to 12.6) for cardiovascular disease (CVD). For chronic obstructive pulmonary disease (COPD), chronic kidney disease (CKD), cerebrovascular disease and cancer, the pooled prevalences were all less than 4%. With the exception of cerebrovascular disease, all the other co-morbidities presented a significantly increased risk for having severe COVID-19. In addition, the risk of mortality was significantly increased in individuals with CVD, COPD, CKD, cerebrovascular disease and cancer.ConclusionsIn individuals with COVID-19, the presence of co-morbidities (both cardiometabolic and other) is associated with a higher risk of severe COVID-19 and mortality. These findings have important implications for public health with regard to risk stratification and future planning.© 2020 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.
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