• Wen-fang Yin, Fu-yu Pei, Xue-dong Wu, Si-xi Liu, Yue-lin He, Jian-yun Liao, Na Li, Ge-yu Chen, Xiao-qing Feng, and Chun-fu Li.
• Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
• Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr 1; 30 (4): 838-41.

ObjectiveTo analyze the risk factors of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation for beta-thalassemia in children.MethodsThe clinical records of 30 children with beta-thalassemia undergoing allogeneic hematopoietic stem cell transplantation between December, 2008 and November, 2009 were analyzed.ResultsHemorrhagic cystitis occurred in 8 of the 33 patients with an incidence of 24.24%, including 1 with grade I, 6 with grade II and 1 with grade III hemorrhagic cystitis. The median time of hemorrhagic cystitis onset was 22.9 days (range 6-35 days) and the median duration was 11.9 days(range 3-27 days). Univariate analysis indicated that the different types of transplantation and acute graft-versus-host disease affect the occurrence of hemorrhagic cystitis. The children with Allo-PBSCT had higher incidence than those receiving Allo-PBSCT+Allo-UBT and Allo-BMT (P<0.05). The children at an age >or=6 years had obviously higher incidence of hemorrhagic cystitis than those at younger ages.ConclusionAge is the major factor that affects the occurrence of hemorrhagic cystitis in children undergoing allogeneic hematopoietic stem cell transplantation for beta-thalassemia.

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