• V F Campos, R Miranda-Ferreira, N S A Taha, G D Teixeira, W T I Souza, C E F Carmo, L A Silva-Neto, I T Gomes, H P Monteiro, E F S Montero, D J Fagundes, A Caricati-Neto, and M O Taha.
• Departments of Pharmacology, Biochemistry, Morphology, and Surgery, Federal University of São Paulo, São Paulo, Brazil.
• Transplant. Proc. 2012 Oct 1; 44 (8): 2313-6.

AbstractTo study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rats were treated with AT (1.5 mg · kg(-1), intravenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the superior mesenteric artery, and/or R (120 minutes). After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained with hematoxylin and eosin for optical microscopy analysis. Compared to the sham group, jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R.Copyright © 2012 Elsevier Inc. All rights reserved.

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