• Nicola Lamberti, Sofia Straudi, Anna Maria Malagoni, Matteo Argirò, Michele Felisatti, Eleonora Nardini, Christel Zambon, Nino Basaglia, and Fabio Manfredini.
• Department of Biomedical Sciences and Surgical Specialties, Section of Sport Sciences, University of Ferrara, Ferrara, Italy.
• Eur J Phys Rehabil Med. 2017 Apr 1; 53 (2): 228-239.

BackgroundChronic stroke survivors are exposed to long-term disability and physical deconditioning, effects that may impact their independence and quality of life. Community-based programs optimizing the dose of exercise therapy that are simultaneously low risk and able to achieve high adherence should be identified.AimWe tested the hypothesis that an 8-week, community-based, progressive mixed endurance-resistance exercise program at lower cardiovascular and muscular load yielded more mobility benefits than a higher-intensity program in chronic stroke survivors.DesignA two-arm, parallel-group, pilot randomized, controlled clinical trial.SettingHospital (recruitment); community-based adapted physical activity center (training).PopulationThirty-five chronic stroke patients (mean age: 68.4±10.4 years; 27 males).MethodsParticipants were randomized to a low-intensity experimental (LI-E; N.=18) or a high-intensity active control group (HI-C; N.=17). Patients in the LI-E group performed over-ground intermittent walking (weeks 1-8) and muscle power training with portable tools (weeks 5-8); patients in the HI-C group executed treadmill walking (weeks 1-8) and strength training with gym machines (weeks 5-8). Changes in mobility, assessed using the 6-Minute Walking Distance test, were the primary outcome. Secondary outcomes included quality of life (Short-Form-36 Questionnaire), gait speed (10-Meter Walking Test), balance (Berg Balance Scale) and muscle performance of the lower limbs (strength and power of the quadriceps and femoral biceps).ResultsAfter 8 weeks, the 6MWD revealed more improvement for the LI-E group than the HI-C group (P=0.009). The SF36 physical activity domain (P=0.012) and peak power of the femoral quadriceps and biceps were also significantly improved for the LI-E group (P=0.008 and P<0.001, respectively) compared with the HI-C. Gait speed, balance and lower-limb strength increased in both groups; no significant differences were noted. The muscle power of the affected limb was the muscle parameter most correlated with mobility in the entire population.ConclusionsA low-intensity exercise program exhibited better results in terms of mobility, quality of life and muscle power compared with a higher-intensity program. Data need to be confirmed in a larger trial.Clinical Rehabilitation ImpactThe effectiveness, low-intensity and possible implementation in poorly equipped community-based settings make the LI-E program potentially suitable for stroke survivors and frail individuals.

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