• Emerging Infect. Dis. · Sep 2004

    Viral loads in clinical specimens and SARS manifestations.

    • I F N Hung, V C C Cheng, A K L Wu, B S F Tang, K H Chan, C M Chu, M M L Wong, W T Hui, L L M Poon, D M W Tse, K S Chan, P C Y Woo, S K P Lau, J S M Peiris, and K Y Yuen.
    • Queen Mary Hospital at the University of Hong Kong, Hong Kong Special Administrative Region, China.
    • Emerging Infect. Dis. 2004 Sep 1; 10 (9): 1550-7.

    AbstractA retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.

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