• Cytokine Growth Factor Rev. · Aug 2020

    Review

    SARS-CoV-2 infection: The role of cytokines in COVID-19 disease.

    • Víctor J Costela-Ruiz, Rebeca Illescas-Montes, Jose M Puerta-Puerta, Concepción Ruiz, and Lucia Melguizo-Rodríguez.
    • Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustración 60, 18016. Granada, Spain; Institute of Biosanitary Research, ibs.Granada, C/ Doctor Azpitarte 4, 4ª planta, 18012. Granada, Spain.
    • Cytokine Growth Factor Rev. 2020 Aug 1; 54: 62-75.

    AbstractCOVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.Copyright © 2020 Elsevier Ltd. All rights reserved.

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