• Zixiao Wang, Jessica L Feig, Diana B Mannschreck, and Bernard A Cohen.
• Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
• Pediatr Dermatol. 2020 Jan 1; 37 (1): 222-223.

AbstractStaphylococcal scalded skin syndrome causes widespread skin denudation primarily in infants < 1 year old. Selection of empiric therapy is complicated by rising rates of antibiotic resistance in community-acquired staphylococcal infections. Consistent with a previous study, this retrospective review found that SSSS-associated isolates were more likely to be clindamycin-resistant and less likely to be methicillin-resistant compared to overall staphylococcal infections. We favor cephalosporins and penicillinase-resistant penicillins (eg, oxacillin) for empiric management of SSSS, with consideration of adding MRSA coverage in communities with high MRSA prevalence or failure to improve following several days of treatment.© 2019 Wiley Periodicals, Inc.

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