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Drug testing and analysis · Jul 2011
ReviewAcute toxicity and withdrawal syndromes related to γ-hydroxybutyrate (GHB) and its analogues γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD).
- David M Wood, Alan D Brailsford, and Paul I Dargan.
- Guy's and St Thomas' NHS Foundation Trust, London, UK. David.Wood@gstt.nhs.uk
- Drug Test Anal. 2011 Jul 1; 3 (7-8): 417-25.
AbstractGamma-hydroxybutyrate (GHB) has been used as a recreational drug since the 1990s and over the last few years there has been increasing use of its analogues gamma-butyrolactone (GBL) and to a lesser extent 1,4-butanediol (1,4BD). This review will summarize the literature on the pharmacology of these compounds; the patterns and management of acute toxicity associated with their use; and the clinical patterns of presentation and management of chronic dependency associated with GHB and its analogues.Copyright © 2011 John Wiley & Sons, Ltd.
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