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- R Heiner Schirmer, Heike Adler, Marcus Pickhardt, and Eckhard Mandelkow.
- Center of Biochemistry (BZH), University of Heidelberg, Heidelberg, Germany.
- Neurobiol. Aging. 2011 Dec 1; 32 (12): 2325.e7-16.
AbstractMethylene blue (MB), the first synthetic drug, has a 120-year-long history of diverse applications, both in medical treatments and as a staining reagent. In recent years there was a surge of interest in MB as an antimalarial agent and as a potential treatment of neurodegenerative disorders such as Alzheimer's disease (AD), possibly through its inhibition of the aggregation of tau protein. Here we review the history and medical applications of MB, with emphasis on recent developments.Copyright © 2011 Elsevier Inc. All rights reserved.
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