• J. Exp. Med. · Jun 2020

    The many faces of the anti-COVID immune response.

    • Santosha A Vardhana and Jedd D Wolchok.
    • Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY.
    • J. Exp. Med. 2020 Jun 1; 217 (6).

    AbstractThe novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.© 2020 Vardhana and Wolchok.

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