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J. Cardiovasc. Pharmacol. · Jan 1988
24-hour noninvasive oscillometric blood pressure monitoring: evaluation of the antihypertensive circadian profile of nitrendipine.
- W Meyer-Sabellek, K L Schulte, B Streitberg, R Gotzen, and A Distler.
- Klinikum Steglitz, Freie Universität Berlin, F.R.G.
- J. Cardiovasc. Pharmacol. 1988 Jan 1; 12 Suppl 4: S22-8.
AbstractThe understanding of blood pressure (BP) and heart rate (HR) variation, circadian changes, and the responses to nonclinical situations has been improved by automated ambulatory recordings. The antihypertensive efficacy of a once-daily regimen (10/20 mg) of nitrendipine was evaluated in detail using the lightest available portable device equipped with an oscillometric blood pressure (BP) recorder (SpaceLabs 90202, weight 480 g) devoid of any electrode. A good antihypertensive effect throughout the day in 20 outpatients could be demonstrated. No significant change of BP could be found in early morning and wake-up period; HR was not significantly affected after 6 weeks of oral therapy.
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