• Elizabeth Morris, Susan A Jebb, Jason Oke, Alecia Nickless, Amy Ahern, Emma Boyland, Ian D Caterson, Jason Halford, Hans Hauner, and Paul Aveyard.
• Nuffield Department of Primary Care Health Sciences, Radcliffe Observatory Quarter, Woodstock Road; NIHR Oxford Biomedical Research Centre, Oxford, UK.
• Br J Gen Pract. 2021 Apr 1; 71 (705): e312e319e312-e319.

BackgroundGuidelines recommend that clinicians identify individuals at high cardiometabolic risk and support weight loss in those with overweight or obesity. However, we lack individual level data quantifying the benefits of weight change for individuals to guide consultations in primary care.AimTo examine how weight change affects cardiometabolic risk factors, and to facilitate shared decision making between patients and clinicians regarding weight loss.Design And SettingObservational analysis using data from two trials of referral of individuals with overweight or obesity in primary care to community weight-loss groups.MethodLinear mixed effects regression modelling examining the association between weight change and change in systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose, glycated haemoglobin (HbA1c), and lipid profile across multiple timepoints (baseline to 24 months). Subgroup analyses examined changes in individuals with hypertension, diabetes, and hyperlipidaemia.ResultsIn total, 2041 participants had a mean (standard deviation) age of 50 (SD 13.5) years, mean baseline weight of 90.6 (14.8) kg and mean body mass index (BMI) of 32.7 (SD 4.1) kg/m2. Mean (SD) weight change was -4.3 (SD 6.0) kg. All outcome measures showed statistically significant improvements. Each 1 kg weight loss was associated with 0.4 mmHg reduction in SBP and 0.3 mmHg reduction in DBP, or 0.5 mmHg and 0.4 mmHg/kg respectively in people with hypertension. Each 1 kg weight loss was associated with 0.2 mmol/mol reduction in HbA1c, or 0.6 mmol/mol in people with diabetes. Effects on plasma lipids were negligible.ConclusionWeight loss achieved through referral to community weight-loss programmes, which are commonly accessible in primary care, can lead to clinically relevant reductions in BP and glucose regulation, especially in those at highest risk.© The Authors.

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