• Benjamin S Wessler and David M Kent.
• Predictive Analytics and Comparative Effectiveness Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 63, Boston, MA 02111, USA; Division of Cardiology, Tufts Medical Center, 800 Washington Street, Box 63, Boston, MA 02111, USA.
• Neurol Clin. 2015 May 1; 33 (2): 491-500.

AbstractPatent foramen ovale (PFO) is common and only rarely related to stroke. The high PFO prevalence in healthy individuals makes for difficult decision making when a PFO is found in the setting of a cryptogenic stroke, because the PFO may be an incidental finding. Recent clinical trials of device-based PFO closure have had negative overall summary results; these trials have been limited by low recurrence rates. The optimal antithrombotic strategy for these patients is also unknown. Recent work has identified a risk score that estimates PFO-attributable fractions based on individual patient characteristics, although whether this score can help direct therapy is unclear. Copyright © 2015 Elsevier Inc. All rights reserved.

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