• Domenico Chirchiglia, Michele Andreucci, Attilio Della Torre, Serena Marianna Lavano, Pasquale Chirchiglia, and Angelo Lavano.
• University of Catanzaro "Magna Graecia", Department of Neurosurgery and Neurophysiopatology Unit, Viale Europa, 88100 Catanzaro, Italy. Electronic address: chirchiglia@unicz.it.
• Neurol Neurochir Pol. 2017 Sep 1; 51 (5): 419-420.

AbstractHemodialysis headache (HDH) is an infrequent new-onset symptom, occurring mainly in old uremic patients. Type of pain is nonspecific, occurs during hemodialysis treatment, assuming features similar to tension-type headache and representing a problem, also as regards the therapy to be taken. International Headache Society (IHS) has placed this form of headache among the headaches disorders of homeostasis. We found a case of new-onset HDH in old uremic man, presenting with migraine aura features. A similar case has not been reported in literature, placing us some questions: why and how does this happen? What are the mechanisms involved? Role of trigeminal-vascular system and cortical spreading depression as regards the aura could be considered, through the activation of neuroinflammatory events, lastly causing migraine aura. Moreover, the administration of flunarizine strongly improved migraine symptoms in our patient, as happens in migraine syndromes. Definitely, this case leads us to think that some mechanisms involved in headaches will need to be further clarified.Copyright © 2017 Polish Neurological Society. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

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