• Sven Märdian, Werner Schmölz, Klaus-Dieter Schaser, Georg N Duda, and Mark Heyland.
• Centre for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address: sven.maerdian@charite.de.
• Clin Biomech (Bristol, Avon). 2019 Dec 1; 70: 89-96.

BackgroundA mechanical characterisation of lag screw fixation plus locking plate - although clinically widely used as either "mixed fixation concept" or absolutely stable fixation - is so far missing. This study aimed to evaluate the influence of an interfragmentary lag screw on the resulting motion at the fracture site of locking plate constructs using a simple fracture at the distal femur.MethodsHuman cadaver femora were in vitro loaded in torsion and axial bending-compression with and without lag screw fixation next to a locking plate fixation. In addition, two plate working lengths were tested. Interfragmentary movement was measured optically.FindingsAxial interfragmentary movement is reduced with lag screw (102 mm plate working length, 1000 N, mean): 0.28 mm versus 0.82 mm. With lag screw, the fracture gap stays closed with mean normal interfragmentary movement ≤0.03 mm. Fracture gap tends to open without lag screw: normal interfragmentary movement up to -0.29 mm. Reduction of shear interfragmentary movement was observed throughout all tested loads and groups. Mean true shear remains generally low with lag screw (≤0.42 mm) compared to without lag screw (≤1.46 mm). We also found that interfragmentary movement variance decreases with lag screw, especially for longer plate working length.InterpretationAn interfragmentary lag screw next to locking bridge plating reduces fragment motion in vitro for a simple fracture pattern and provides a sufficient tool to decrease detrimental shear movements. Prospective clinical trials with interfragmentary lag screw fixation should prove these findings in wide clinical use to treat simple fracture patterns.Copyright © 2019 Elsevier Ltd. All rights reserved.

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