• Gonzalo Labarca, Mario Henriquez-Beltran, Faryd Llerena, Gustavo Erices, Jaime Lastra, Daniel Enos, Daniela Castillo, Marco Fraga, Liliana Lamperti, Valeska Ormazabal, Benilde Riffo, Daniel Rubilar, Rocio Sanhueza, Jaime Vasquez, Carolina Villanueva, Gloria Horta, Felipe Sanhueza, Pedro Melo, Jorge Dreyse, Jorge Jorquera, Sebastian Fernandez-Bussy, Jessica Gonzalez, Ferran Barbe, Estefania Nova-Lamperti, and CONTAC19 Consortium.
• Faculty of Medicine, Universidad de Concepción, Concepcion, Chile; Complejo Asistencial Dr. Victor Rios Ruiz, Los Angeles. Chile; Molecular and Translational Immunology Laboratory, Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepcion, Concepcion, Chile. Electronic address: glabarcat@gmail.com.
• Sleep Med. 2021 Feb 19.

IntroductionPatients with severe COVID-19 develops an acute respiratory distress syndrome (ARDS), requiring admission to the intensive care unit. COVID-19 also reports an increased prevalence of comorbidities, similar to patients with Sleep disorder breathing (SDB).ObjectivesTo evaluate the association between undiagnosed SDB and the risk of ARDS and pulmonary abnormalities in a cohort of patients' survivors of COVID-19 between 3 and 6 months after diagnosis.MethodsProspective cohort study of patients who developed ARDS during hospitalization due to COVID-19 compared with a control group of patients who had COVID-19 with mild to moderate symptoms. All patients were evaluated between the 12th and 24th week after SARS-CoV-2 infection. The evaluation includes persistent symptoms, lung diffusing capacity of carbon monoxide (DLCO), chest CT scan and home sleep apnea test. SDB was diagnosed by the respiratory disturbance index ≥5 ev/h. The association between SDB and ARDS, the hazards of lung impairment and the hazard ratios (HR) were analyzed.ResultsA total of 60 patients were included (ARDS: 34 patients, Control: 26 patients). The mean follow-up was 16 weeks (range 12-24). ARDS reported a high prevalence of SDB (79% vs. 38% in control group). A total of 35% reported DLCO impairment, and 67.6% abnormal chest CT. SDB was independently associated to ARDS, OR 6.72 (CI, 1.56-28.93), p < 0.01, and abnormal Chest CT, HR 17.2 (CI, 1.68-177.4, p = 0.01). Besides, ARDS, days in mechanical ventilation, male gender were also associated with an increased risk of abnormal chest CT.ConclusionUndiagnosed SDB is prevalent and independently associated with ARDS. In addition, undiagnosed SDB increased the hazard of abnormal Chest CT in the midterm.Study RegisterISRCTN16865246.Copyright © 2021 Elsevier B.V. All rights reserved.

6 keywords...

hide…