• Philipp Baumann, Sotirios Fouzas, Isabelle Pramana, Beate Grass, Oliver Niesse, Christoph Bührer, Katharina Spanaus, and Sven Wellmann.
• Department of Neonatology, University Hospital Zurich, Zurich, Switzerland.
• Neonatology. 2015 Jan 1; 108 (4): 293-6.

BackgroundBronchopulmonary dysplasia (BPD) is a common complication in preterm infants. Clinical prediction of BPD at an early stage in life is difficult. Plasma proendothelin-1 (CT-proET-1) is a lung injury biomarker in pulmonary hypertension and respiratory distress.ObjectiveTo assess the prognostic ability of CT-proET-1 in BPD.MethodsIn 227 prospectively enrolled preterm infants born at <32 weeks gestational age (GA), plasma CT-proET-1 was measured at birth, day of life (DOL) 2, 3, 6 and 28, and at 36 weeks postmenstrual age (PMA). BPD was defined as mild in infants requiring supplemental oxygen at DOL 28 and moderate/severe in those requiring it at 36 weeks PMA.ResultsThe predictive ability of CT-proET-1 for any BPD was poor at birth [area under the ROC curve (AUC) 0.654, 95% CI 0.494-0.814], moderate at DOL 2 and 3 (AUC 0.769, 95% CI 0.666-0.872) and excellent at DOL 6 (AUC 0.918, 95% CI 0.840-0.995). Multivariable regression analysis revealed that CT-proET-1 levels at DOL 2, 3, 6 and 28 were strongly related to the duration of oxygen supplementation, independently of GA and the duration of respiratory support.ConclusionsCT-proET-1 is a novel promising biomarker for predicting the development of BPD in preterm infants when measured at the end of the first week of life.© 2015 S. Karger AG, Basel.

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