• J. Biol. Chem. · Feb 2008

    Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex.

    • Yael Gore, Diana Starlets, Nitsan Maharshak, Shirly Becker-Herman, Utako Kaneyuki, Lin Leng, Richard Bucala, and Idit Shachar.
    • Department of Immunology, the Weizmann Institute of Science, Rehovot 76100, Israel.
    • J. Biol. Chem. 2008 Feb 1; 283 (5): 2784-92.

    AbstractMacrophage migration inhibitory factor (MIF) is an upstream activator of innate immunity that regulates subsequent adaptive responses. It was previously shown that in macrophages, MIF binds to a complex of CD74 and CD44, resulting in initiation of a signaling pathway. In the current study, we investigated the role of MIF in B cell survival. We show that in B lymphocytes, MIF initiates a signaling cascade that involves Syk and Akt, leading to NF-kappaB activation, proliferation, and survival in a CD74- and CD44-dependent manner. Thus, MIF regulates the adaptive immune response by maintaining the mature B cell population.

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