• Abigail A Marsh, Elizabeth C Finger, Katherine A Fowler, Jurkowitz Ilana T N ITN Mood & Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA., Julia C Schechter, Henry H Yu, Daniel S Pine, and Blair R J R RJR Mood & Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA..
• Mood & Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA; Department of Psychology, Georgetown University, Washington DC, USA. Electronic address: aam72@georgetown.edu.
• Psychiatry Res. 2011 Dec 30; 194 (3): 279-286.

AbstractWe used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI while they categorized illegal and legal behaviors in a moral judgment implicit association task. fMRI data were then analyzed using random-effects analysis of variance and functional connectivity. Youths with psychopathic traits showed reduced amygdala activity when making judgments about legal actions and reduced functional connectivity between the amygdala and orbitofrontal cortex during task performance. These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population.2011 Elsevier Ireland Ltd. All rights reserved.

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