• René Aquarius, Astrid Maria van der Zijden, Jasper Homminga, Nico Verdonschot, and Esther Tanck.
• *Radboud University Nijmegen Medical Centre, Orthopaedic Research Laboratory, Nijmegen, the Netherlands; and †Twente University, Laboratory for Biomechanical Engineering, Enschede, the Netherlands.
• Spine. 2013 Nov 15;38(24):2092-7.

Study DesignAn in vitro cadaveric study.ObjectiveTo determine whether percutaneous vertebroplasty (PVP) with a clinically relevant amount of bone cement is capable of causing stress peaks in adjacent-level vertebrae.Summary Of Background DataIt is often suggested that PVP of a primary spinal fracture causes stress peaks in adjacent vertebrae, thereby leading to additional fractures. The in vitro studies that demonstrated this relationship, however, use bigger volumes of bone cement used clinically.MethodsTen fresh-frozen vertebrae were loaded until failure, while registering force and displacement as well as the pressure under the lower endplate. After failure, the vertebrae were augmented with clinically relevant amounts of bone cement and then again loaded until failure. The force, displacement, and pressure under the lower endplate were again registered.ResultsStress peaks were not related to the location of the injected bone cement. Both failure load and stiffness were significantly lower after augmentation.ConclusionOn the basis of our findings, we conclude that vertebral augmentation with clinically relevant amounts of bone cement does not lead to stress peaks under the endplate. It is therefore unlikely that PVP, in itself, causes detrimental stresses in the adjacent vertebrae, leading to new vertebral fractures.Level Of EvidenceN/A.

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