• Francisco Gomez-Delgado, Juan Francisco Alcala-Diaz, Ana Leon-Acuña, Javier Lopez-Moreno, Javier Delgado-Lista, Beatriz Gomez-Marin, Irene Roncero-Ramos, Elena M Yubero-Serrano, Oriol Alberto Rangel-Zuñiga, Cristina Vals-Delgado, Raul M Luque, Jose M Ordovas, Jose Lopez-Miranda, and Pablo Perez-Martinez.
• Lipids and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, Cordoba, Spain.
• Eur. J. Clin. Invest. 2019 Aug 1; 49 (8): e13146.

BackgroundWe try to explore whether long-term consumption of two healthy dietary patterns (low-fat [LF] diet or Mediterranean diet [MedDiet]) interacts with the apolipoprotein E (APOE) single-nucleotide polymorphisms (SNPs: rs439401, rs440446 and rs7412) modulating postprandial hypertriglyceridemia (ppHTG) in coronary heart disease (CHD) patients.Methods And ResultsWe selected patients from the CORDIOPREV study with genotyping and who underwent an oral fat load test (FLT) at baseline and after 3 years follow-up (n = 506). After 3 years of follow-up, we found a gene-diet interaction between the APOE rs439401 SNP and MedDiet. Specifically, T-allele carriers in the MedDiet group showed a more significant decrease in postprandial triglycerides (TG: P = 0.03) and large triacylglycerol-rich lipoproteins (TRLs) TG (large TRLs TG; P = 0.01) compared with CC subjects. Consistently, the area under the curve of TG (AUC-TG; P-interaction = 0.03) and AUC-large TRLs TG (P-interaction = 0.02) were significantly lower in T-allele carriers compared with CC subjects.ConclusionsThe long-term consumption of a MedDiet modulates ppHTG through APOE genetic variants in CHD patients. This gene-diet interaction may contribute to a more precise dietary advice in CHD patients.© 2019 Stichting European Society for Clinical Investigation Journal Foundation.

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