• Alba Chavarría-Miranda, Ángel L Guerrero, Blanca Talavera, Enrique Martínez-Pías, Javier Trigo-López, Álvaro Sierra, and David García-Azorín.
• Headache Unit, Neurology Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
• Pain Med. 2021 May 21; 22 (5): 1158-1166.

ObjectiveLinear headache has been recently described as an episodic or chronic unilateral pain distributed along a fixed linear trajectory, which combines some characteristics of epicrania fugax and nummular headache. The aim of this study was to describe the clinical characteristics and therapeutic response of a series of 16 new patients.DesignThis is an observational study with a series of cases.SettingThe study period encompassed June 2014 to June 2019. Demographic, clinical, and therapeutic response data were recorded.MethodsWe included all consecutive patients who presented pain with the following characteristics: sharply contoured, fixed in size and shape, with linear shape, without movement along a trajectory, and not circumscribed to the territory of any nerve.ResultsTwelve patients were women, and four were men. The mean age at onset was 40.1 years. Pain was described as pressing in seven patients, burning in five, and electric or stabbing in two each. Symptomatic treatment had been used by 13 patients (81.2%), with analgesics being the most frequent treatment used. Thirteen patients received preventive treatment. The response to oral medications and anesthetic blockade was insufficient. OnabotulinumtoxinA was used in six cases, with an optimal (>75%) response observed in half.ConclusionLinear headache appears to be a distinct headache syndrome from epicrania fugax or nummular headache. Preventive treatment is often required. The drug with the best response was onabotulinumtoxinA.© The Author(s) 2021. Published by Oxford University Press on behalf of the American Academy of Pain Medicine.All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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