• N. Engl. J. Med. · Mar 2021

    Case Reports

    Spermatogonium-Derived Complete Hydatidiform Mole.

    • Hirokazu Usui and Makio Shozu.
    • From the Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
    • N. Engl. J. Med. 2021 Mar 11; 384 (10): 936-943.

    AbstractA complete hydatidiform mole (CHM) is a conceptus with only sperm-derived chromosomes. Here, we report on a CHM with genomic DNA identical to that of the paternal somatic cells. The CHM developed in a woman who had undergone intrauterine implantation of a blastocyst obtained through in vitro injection of a presumed round spermatid into one of her oocytes. The CHM was genetically identical to peripheral white cells of her husband and contained no maternally derived nuclear DNA. We hypothesize that a spermatogonium, rather than a round spermatid, was inadvertently selected for the procedure. The CHM developed into a gestational trophoblastic neoplasia, which resolved after chemotherapy. (Funded by the Japan Society for the Promotion of Science.).Copyright © 2021 Massachusetts Medical Society.

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