• Pathologie-biologie · Apr 1992

    Review Clinical Trial

    [Beta-blockers and migraine].

    • H Massiou and M G Bousser.
    • Service de Neurologie, Hôpital Saint-Antoine, Paris, France.
    • Pathol. Biol. 1992 Apr 1; 40 (4): 373-80.

    AbstractFive beta-blocking agents are effective as long-term prophylactic treatment of migraine: propranolol, metoprolol, timolol, atenolol and nadolol. Propranolol has been most extensively studied and proved effective in 19 of 21 controlled trials. The optimal dose should be determined on a case-by-case basis, by increasing the daily dosage gradually. Among the properties of beta-blockers, the only one which appears to be correlated--albeit negatively--with effectiveness on migraine is intrinsic sympathomimetic activity (ISA): drugs without ISA are effective against migraine whereas partial agonists are not. The mode of action of beta-blockers in migraine is still poorly understood; one of the most cogent current hypotheses involves reduction of brain catecholaminergic hyperactivity.

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