• J Clin Neurosci · Feb 2018

    Palpebral portion of the orbicularis oculi muscle to repetitive nerve stimulation testing: A potential assessment indicator in patients with generalized myasthenia gravis.

    • Chong Yan, Jie Song, Song Pang, Fangfang Yi, Jianying Xi, Lei Zhou, Ding Ding, Weifeng Wang, Kai Qiao, and Chongbo Zhao.
    • Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China.
    • J Clin Neurosci. 2018 Feb 1; 48: 238-242.

    AbstractRepetitive nerve stimulation (RNS) is a valuable diagnostic method for myasthenia gravis (MG). However, its association with clinical severity was scarcely studied. We reviewed medical records and retrospectively enrolled 121 generalized MG patients. Sensitivity of different muscles to RNS and clinical scoring systems was evaluated. RNS testing revealed facial muscles have the highest positive rate, followed by proximal muscles and distal muscles, with the palpebral portion of the orbicularis oculi muscle most sensitive. Amplitude decrement of compound muscle action potential (CMAP) in the palpebral portion of the orbicularis oculi muscle is related to quantitative myasthenia gravis (QMG) scores, MG-specific manual muscle testing (MMT) scores and myasthenia gravis-related activities of daily living (MG-ADL) scores. We suggest that RNS testing of the palpebral portion of the orbicularis oculi muscle is a potential assessment indicator in patients with generalized MG.Copyright © 2017 Elsevier Ltd. All rights reserved.

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