• H Buschke, G Kuslansky, M Katz, W F Stewart, M J Sliwinski, H M Eckholdt, and R B Lipton.
• The Saul R. Korey Department of Neurology, Rose F. Kennedy Center for Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
• Neurology. 1999 Jan 15; 52 (2): 231-8.

ObjectivesTo validate a sensitive and specific screening test for AD and other dementias, assess its reliability and discriminative validity, and present normative data for its use in various applied settings.BackgroundTo improve discrimination in screening for AD and dementia, we developed the Memory Impairment Screen (MIS), a 4-minute, four-item, delayed free- and cued-recall test of memory impairment. The MIS uses controlled learning to ensure attention, induce specific semantic processing, and optimize encoding specificity to improve detection of dementia.MethodsEquivalent forms of the MIS were given at the beginning and end of the testing session to assess alternate forms reliability. Discriminative validity was assessed in a criterion sample of 483 aged individuals, 50 of whom had dementia according to Diagnostic and Statistical Manual of Mental Disorders (3rd ed., revised) criteria.ResultsThe MIS had good alternate forms reliability, high construct validity for memory impairment, and good discriminative validity in terms of sensitivity, specificity, and positive predictive value. We present normative data for use in settings with different base rates (prevalences) of AD and dementia.ConclusionThe MIS provides efficient, reliable, and valid screening for AD and other dementias.

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