• Shingo Kakeda, Koichiro Futatsuya, Satoru Ide, Keita Watanabe, Mari Miyata, Junji Moriya, Atsushi Ogasawara, Toru Sato, Hidekuni Narimatsu, Kazumasa Okada, Takenori Uozumi, Tian Liu, Yi Wang, and Yukunori ... more Korogi. less
• Department of Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. Electronic address: kakeda@med.uoeh-u.ac.jp.
• Acad Radiol. 2015 Nov 1; 22 (11): 1427-32.

Rationale And ObjectivesQuantitative susceptibility mapping (QSM) is a novel technique which allows determining the bulk magnetic susceptibility distribution of tissue in vivo from gradient echo magnetic resonance (MR) phase images. Our purpose was to evaluate if there is additional diagnostic value of QSM images in detecting the cortical gray matter involvement in multiple sclerosis (MS) patients.Materials And MethodsOur institutional review board approved this study. Conventional MR imaging, including T2-weighted imaging and two- or three-dimensional fluid-attenuated inversion recovery images, and QSM imaging examinations were performed in 27 patients (19 male and eight female) with MS. Two radiologists (radiologists 1 and 2) assessed the MS lesions in the following 3 anatomic regions: intracortical, mixed white matter-gray matter (WM-GM), and juxtacortical regions. The numbers of lesions per region category were compared between conventional MR images with and without QSM images.ResultsFor radiologists 1 and 2, QSM images identified 6 (50.0%) and 7 (50.0%) additional lesions that were not seen in the conventional MR images, respectively. In a lesion-by-lesion analysis, the substantial fraction (20 [25.3%] of 79 at radiologist 1, 22 [29.7%] of 74 at radiologist 2) of juxtacortical white matter lesions on the conventional MR images were scored as mixed WM-GM lesions with QSM images.ConclusionsOur preliminary results suggest that the MR imaging with QSM may increase the sensitivity in cortical lesion detection in the MS brain and improved distinction between juxtacortical and mixed WM-GM lesions.Copyright © 2015 AUR. Published by Elsevier Inc. All rights reserved.

21 keywords...

hide…