• Bhawna Sirohi, Shailesh V Shrikhande, Vinay Gaikwad, Amol Patel, Shraddha Patkar, Mahesh Goel, Munita Bal, Atul Sharma, Raj Kumar Shrimali, Vikram Bhatia, Suyash Kulkarni, Deep Narayan Srivastava, Tanvir Kaur, R S Dhaliwal, Goura Kishor Rath, and Indian Council of Medical Research Guidelines Working Group.
• Department of Medical Oncology, Apollo Proton Cancer Centre, Chennai, India.
• Indian J Med Res. 2020 Nov 1; 152 (5): 468-474.

AbstractThis document aims to assist oncologists in making clinical decisions encountered while managing their patients with hepatocellular carcinoma (HCC), specific to Indian practice, based on consensus among experts. Most patients are staged by Barcelona Clinic Liver Cancer (BCLC) staging system which comprises patient performance status, Child-Pugh status, number and size of nodules, portal vein invasion and metastasis. Patients should receive multidisciplinary care. Surgical resection and transplant forms the mainstay of curative treatment. Ablative techniques are used for small tumours (<3 cm) in patients who are not candidates for surgical resection (Child B and C). Patients with advanced (HCC should be assessed on an individual basis to determine whether targeted therapy, interventional radiology procedures or best supportive care should be provided. In advanced HCC, immunotherapy, newer targeted therapies and modern radiation therapy have shown promising results. Patients should be offered regular surveillance after completion of curative resection or treatment of advanced disease.

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