• Zivković Nikola, Mihailović Dragan, Zaklina Mijović, and Maja Jovicić Milentijević.
• Institute of Pathology, Faculty of Medicine, University of Nis, Nis, Serbia. nikolazivkovich@gmail.com
• Vojnosanit Pregl. 2012 Jul 1; 69 (7): 631-4.

IntroductionPrimary melanocytosis of the leptomeninges is a rare tumor, most likely originating from the melanocytes in the leptomeninges. The average survival is only about 5 months.Case ReportA 61-years-old woman presented with headache, amaurosis and hallucinations lasted for two months, and she had been treated at the Clinic for Psychiatry and Clinic for Infectious Diseases. The cerebrospinal fluid analysis showed a lower level of glucose and a higher level of proteins. Small shaded areas of basal leptomeninges and hydrocephalus were found by computed tomography and magnetic resonance imaging. The autopsy showed a dark brown mass on basal leptomeninges with blurred boundaries. No pigmented skin lesions were found. Histopathological analysis revealed a primary leptomeningeal melanocytosis.ConclusionPrimary leptomeningeal melanocytosis is a rare tumor, difficult to diagnose. This case is being presented for its specificity, since this diagnosis is not frequently seen in practice.

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