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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Jun 2003
[Changes in interleukin-1beta in serum and bronchoalveolar lavage fluid in the patient with acute respiratory distress syndrome].
- Xian-rong Luo, Wei-ling Wu, Lin Wang, Xiao-qun Ye, and Dan Zhang.
- Department of Respiratory Disease, Airforce Hospital of People's Liberation Army, Guangzhou, 510602 Guangdong, China.
- Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Jun 1; 15 (6): 365-6.
ObjectiveTo study the role of interleukin-1beta (IL-1beta) in the pathogenesis of acute respiratory distress syndrome (ARDS).MethodsThe bronchoalveolar lavage fluid (BALF) and serum in 13 patients with ARDS and 9 healthy controls were collected. The contents of IL-1beta were measured by enzyme-linked immunoadsorbent assay(ELISA).ResultsThe levels of IL-1beta in BALF [(144.67+/-80.79)ng/L] and serum [(45.71+/-7.09)ng/L] in patients with ARDS were significantly higher than those in the control groups [(20.39+/-1.87)ng/L, P=0.000; (35.06+/-5.46)ng/L, P=0.001, respectively], and the levels of IL-1beta in BALF were also significantly higher than those of the serum in the patients with ARDS (P=0.000).ConclusionThe results indicate that IL-1beta is involved in the pathogenesis of ARDS. Early determination of IL-1beta level in BALF may be more valuable in the evaluation of disease process of ARDS.
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