• Lalchhandami Colney, Nikhil Tandon, GargPramod KumarPKDepartment of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India., Nandita Gupta, Sushma Sagar, Amit Gupta, Atin Kumar, and Subodh Kumar.
• Division of Trauma Surgery and Critical Care, Department of Surgical Disciplines, JPN Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, 29, India.
• Eur J Trauma Emerg Surg. 2022 Feb 1; 48 (1): 97-105.

IntroductionInjury to the pancreas may lead to significant morbidity and mortality. We aim to assess pancreatic endocrine and exocrine functions and evaluated morphological regenerations of pancreas following partial pancreatectomy in patients with pancreatic trauma.MethodsThe study was performed between June 2016 and December 2017. Endocrine functions were assessed at the time of admission and at 6 months follow-up with 75 g oral glucose tolerance test (OGTT), serum insulin and C-peptide levels and HbA1c estimation and exocrine functions were assessed with fecal elastase test. Pancreatic volumetry was done with imaging scan at 1 month and 6 months post discharge.ResultsTwenty patients were studied with a median age of 30 years (range18-48) at the time of injury. All the patients were normoglycemic on admission; only one patient who underwent pancreatic resection developed diabetes mellitus at follow-up. Eight patients (40%) were found to be prediabetic by American Diabetes Association (ADA) criteria. Eleven patients (55%) had pancreatic exocrine insufficiency. Pancreatic volume increment, from the mean pancreatic volume of 48.65 to 54.29 cm3, was noted in patients who underwent partial pancreatectomy.ConclusionsPatients with pancreatic trauma may develop biochemical endocrine and exocrine insufficiencies following pancreatic resection. Pancreatic volume increment requires further research in a larger study.© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.

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