• Neurosurgery · Nov 2013

    Case Reports

    Deep brain stimulation for obsessive-compulsive disorder affects language: a case report.

    • A Rosaura Polak, Anke B Witteveen, Mariska Mantione, Martijn Figee, Pelle de Koning, Miranda Olff, Pepijn van den Munckhof, P Richard Schuurman, and Damiaan Denys.
    • *Department of Psychiatry and §Department of Neurosurgery, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; ‡Arq Psychotrauma Expert Group, Diemen, the Netherlands; ¶Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
    • Neurosurgery. 2013 Nov 1;73(5):E907-10; discussion E910.

    Background And ImportanceDeep brain stimulation (DBS) is an effective treatment for patients with refractory neuropsychiatric disorders. Along with symptom improvement, DBS may have concurrent behavioral effects that help to unravel the role of specific brain circuitries in complex human behavior.Clinical PresentationThis article reports on 2 patients with obsessive-compulsive disorder who received DBS targeted at the nucleus accumbens that resulted in a temporary change of accent and use of vocabulary.ConclusionChanges in accent and speaking manners are most likely related to direct DBS stimulation effects of the electrode targeted at the nucleus accumbens. The shift in accent, resembling foreign accent syndrome after injuries in brain language centers, has not been reported before in the course of DBS. Induction of aggressive vocabulary may be related to transient hypomanic behavior after DBS.

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