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Review Meta Analysis
A systematic review of biocompatible cardiopulmonary bypass circuits and clinical outcome.
- Marco Ranucci, Anna Balduini, Antonio Ditta, Alessandra Boncilli, and Simonetta Brozzi.
- Department of Cardiothoracic-Vascular Anesthesia and Intensive Care, IRCCS Policlinico S. Donato, Milan, Italy. cardioanestesia@virgilio.it
- Ann. Thorac. Surg. 2009 Apr 1; 87 (4): 1311-9.
AbstractThis systematic review and meta-analysis explores the clinical efficacy of biocompatible surfaces for cardiopulmonary bypass in adults. Thirty-six randomized controlled trials were retrieved for a total of 4360 patients. Patients treated with biocompatible circuits had a lower rate of packed red cells transfusions and atrial fibrillation, and shorter durations of stay in the intensive care unit. When the analysis was limited to high-quality studies, only a reduction in atrial fibrillation rate and a shorter stay in the intensive care unit remained significantly associated with the use of biocompatible surfaces. Using biocompatible surfaces without other measures to contain blood activation results in a limited clinical benefit.
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