• A Bertolino, E Mastucci, V Porro, L Corfiati, M Palermo, U Ecari, and G Ceccarelli.
• Casa Divina Provvidenza, Bisceglie, Bari, Italy.
• J. Int. Med. Res. 1989 Sep 1; 17 (5): 455-60.

AbstractA total of 45 patients with generalized anxiety disorder were treated twice daily for 2 weeks, on a double-blind basis, with 0.5 mg etizolam, 0.5 mg alprazolam or 3 mg bromazepam, and symptoms were assessed using Hamilton's rating scale for anxiety and Hamilton's rating scale for depression. Patients then received the same drug for a further 2 weeks, the drugs being given three times daily if a poor response was observed during the first 2 weeks. All drugs displayed equivalent anxiolytic activity after 2 weeks, but etizolam displayed a progressive increase in anxiolytic activity over 4 weeks of treatment. Etizolam also possessed a more marked antidepressant effect than did alprazolam or bromazepam. There were no differences in the tolerability of the three drugs.

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