• Expert Rev Anticancer Ther · Feb 2015

    Review

    Role of miRNA in head and neck squamous cell carcinoma.

    • Yaghma Masood, Cheah Yoke Kqueen, and Pathmanathan Rajadurai.
    • Faculty of Dentistry, Centre of Oral and Maxillofacial Diagnostics and Medicine Studies, Universiti Teknologi MARA, Level 19, Tower 2, Shah Alam, 40450, Malaysia.
    • Expert Rev Anticancer Ther. 2015 Feb 1; 15 (2): 183-97.

    AbstractHead and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Evidence suggests that miRNAs play an important role in progression, recurrence, metastasis and postoperative survival of HNSCC. Studies have investigated the utility of miRNAs as diagnostic/prognostic tools and as potential therapeutic targets and biomarkers that may improve the management and outcomes of HNSCC. The aim of this article is to review the current literature on aberrant expression profiles of miRNAs in biopsy samples of HNSCC and their role in cancer development, metastasis, prognosis and survival of these patients. This review gives an overview that miRNAs deregulation play major role in the development of HNSCC. They offer the potential to be used as biomarkers or novel therapeutic targets. Future research is required to test their use in both of these fields.

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