• Mingyi Jing, Qianying Yu, Baohua Zhu, Fan Yuan, Jie Zhang, Li Peng, Wenxia Lin, and Mingling Chen.
• Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P. R. China.
• Medicine (Baltimore). 2021 Mar 12; 100 (10): e24418e24418.

BackgroundChronic hand eczema (CHE) is a recurrent, frequently disabling skin condition that requires daily skin care to prevent transepidermal water loss, posing a significant burden of society and economy. In recent years, topical 0.05% clobetasol cream is widely used for the treatment of CHE for its efficacy, tolerability and safety. Whereas, no systematic review and meta-analysis has been updated up to now. Therefore, this work aims to assess the effectiveness and safety of topical 0.05% clobetasol cream in patients with CHE.MethodsStudy on topical 0.05% clobetasol cream for CHE will be searched from their inception to December, 2020 with the language restrictions of English and Chinese in 8 databases (PubMed, Cochrane Library, Embase, the web of science, VIP, CNKI, CBM, and WAN FANG). According to the heterogeneity test, a fixed or random-effect model will be used to synthesize data. The primary outcome is the proportion of patients achieving more than 75% reduction in signs and symptoms according to the Hand Eczema Severity Index (HECSI). The secondary outcomes include: scored for 4 different characteristics of the lesions (redness, scaling, lichenification, and pruritus), QoL questionnaire, adverse events, and recurrence events. STATA 13.0 and Review Manager software 5.3 will be used for analysis and synthesis. Two or more reviewers will independently conduct the selection of studies, data extraction, and data analysis.ResultsThe results of the study expect to provide a high-quality, evidence-based recommendation on topical 0.05% clobetasol cream in the treatment of CHE for clinicians.ConclusionThe study will provide scientific and useful evidence for better use of topical 0.05% clobetasol cream in treating CHE.Ethics And DisseminationThis study is a protocol for an overview of SRs/MAs that did not involve individual data. Thus, ethical approval is not required.Osf Registration NumberDOI 10.17605/OSF.IO/SPHVZ.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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