• Medicine · Mar 2021

    Case Reports

    Using human umbilical cord mesenchymal stem cells combined with allogenic platelet-rich fibrin membrane for the treatment of dual limb ischemia in an elderly patient: A case report.

    • Wendong Ju, Simao Fu, Jun Huang, Bishuang Li, Li Wang, Minmin Zheng, Haojie Song, Quanyong Li, Qiaoyun Zhou, and Meixing He.
    • Department of Hematology Rheumatology.
    • Medicine (Baltimore). 2021 Mar 12; 100 (10): e25068e25068.

    RationaleTo describe the clinical effects of human umbilical cord mesenchymal stem cells (UCMSCs) combined with allogenic platelet-rich fibrin (PRF) for the treatment of lower limb ischemia in an elderly patient.Patient ConcernsThe patient was a 93-year-old Chinese woman with bilateral foot gangrene and ulcers lasting for 6 months. She had a prior history of Behcet's disease.DiagnosesThe admitting diagnosis for this episode was atherosclerosis bilateral limb ischemia.InterventionsFirst, treatment consisting of immunosuppressants, anticoagulation, antiplatelets, and anti-microbials were instituted. A UCMSC suspension was administered intravenously and injected into the lower limbs twice. An allogenic PRF membrane was externally applied 15 times over the lower limbs.OutcomesThe patient's pain improved and the 6 ulcers healed.LessonsThe combination of UCMSCs with a PRF membrane for the treatment of lower limb ischemia in an elderly patient is effective and safe. More and larger trials are needed before incorporating this therapy into mainstream treatment.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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