• Chao Liu, Jing Yang, Weiwei Dong, and Jinyan Yuan.
• The NO.2 Hospital of Baoding Department of Gastroenterology.
• Medicine (Baltimore). 2021 Mar 19; 100 (11): e25138e25138.

BackgroundGastrointestinal complications and malnutrition are common problems that affect postoperative rehabilitation and survival of patients with esophageal cancer. Evidence has shown that probiotics have a positive effect on improving gastrointestinal complications and nutritional status of patients with esophageal cancer after surgery, but there is a lack of prospective studies on this topic. We designed this prospective randomized controlled trial to evaluate the effects of probiotics on gastrointestinal complications and nutritional status in patients with postoperative esophageal cancer.MethodsThis is a prospective, randomized, double-blind, placebo-controlled trial. It was approved by the Clinical Research Ethics Committee of our hospital. 192 patients will be randomly divided into probiotics group and the placebo group in a 1:1 ratio. After operation, probiotics and placebo will be given orally for 8 weeks. The indexes of nutritional status and incidence of digestive tract complications will be recorded and the data will be analyzed by SPSS 18.0 software.DiscussionThis study will evaluate the effect of probiotics on gastrointestinal complications and nutritional status of postoperative patients with esophageal cancer. The results of this study will provide clinical basis for the use of probiotics in postoperative treatment of esophageal cancer.Trial RegistrationOSF Registration number: D DOI 10.17605/OSF.IO/QHW86.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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